Genetic variability in the E6 and E7 oncogenes of HPV52 and its prevalence in the Taizhou area, China - Virology Journal - Virology Journal
Persistent high-risk HPV infection has been identified as a major risk factor for cervical cancer. In China, the infection rates of high-risk HPV, such as HPV16, 18, 52, and 58, increase with the severity of cervical lesions [5, 7]. The overall HPV infection rate (21.3%) of this study was significantly different from that of Yangqu (8.9%), Xinjiang (14.0%), and Shandong (28.4%) but similar to that of other regions in Southeast China, such as Hangzhou (22.4%) and Jiangxi (22.5%) [15,16,17,18,19]. Many factors, including different economic conditions, cultural diversity, HPV vaccine awareness and lifestyles, might be the reasons for the differences in HPV infection rates in different geographical regions [7, 20, 21]. In this study, HPV52 was the most prevalent HPV type, followed by HPV58, 53, 16, 81, 39, 61, and 18. It is worth noting that the Gardasil 9-valent prophylactic vaccine approved for marketing in China in 2016 mainly targets HPV 6, 11, 16, 18, 31, 33, 45, 52, and 58. Therefore